Synergistic interaction between histamine and ouabain on ventricular fibrillation threshold
نویسندگان
چکیده
منابع مشابه
Fibrillation threshold of premature ventricular responses.
• Asynchrony of recovery from the refractory state has been emphasized repeatedly as a major factor in the induction of ventricular fibrillation by strong stimuli applied during the "vulnerable" period. The role of asymmetry of refractoriness, excitability, and conduction has been appraised thoroughly by Brooks et al. Some of the postulates proposed in their discussion have been tested and supp...
متن کاملThe effects of ventricular fibrillation duration and site of initiation on the defibrillation threshold during early ventricular fibrillation.
OBJECTIVES The purpose of this study was to determine if the defibrillation threshold (DFT) is lower during the first few cycles of ventricular fibrillation (VF) than after 10 s of VF and, if so, if the effect is caused by local or global factors. BACKGROUND The DFT may be low very early during VF because: (1) for the first few cycles VF arises from a localized region close to a defibrillatio...
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The effects of external divalent cations on drug-receptor interaction were examined using guinea pig taenia. The effects of histamine on membrane potential of taenia in various solutions were also examined using the sucrose gap method. Ca2+ and Me2+ played an important role in the combination of histamine with its receptor. Sr2+, Mn2+ and Co2+ do not substitute for. Ca2+ and Me2+ in this intera...
متن کاملSynergistic interaction between exercise and insulin on peripheral glucose uptake.
The interaction of exercise and insulin on glucose metabolism was examined in 10 healthy volunteers. Four study protocols were used: study 1: plasma insulin was raised by approximately 100 microunits/ml while plasma glucose was maintained at basal levels for 2 h (insulin clamp). Study 2: subjects performed 30 min of bicycle exercise at 40% of VO2 max. Study 3: an insulin clamp was performed as ...
متن کاملEffect of the ouabain-quinidine interaction on left ventricular and left atrial function in conscious dogs.
The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p less than 0.05) increased LV dP/dt, LV and LA fractional shortening and LV and LA velocity of circumferential fib...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1985
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1985.tb08826.x